133 Multimodal analyses of vitiligo skin identifies tissue characteristics of stable disease
نویسندگان
چکیده
Vitiligo is an autoimmune skin disease that characterized by the progressive destruction of melanocytes autoreactive CD8+ T cells. Melanocyte in active vitiligo mediated cells but why white patches stable persist poorly understood. The interaction between immune cells, melanocytes, and keratinocytes situ human has been difficult to study due lack proper tools. We combine non-invasive multiphoton microscopy (MPM) imaging single-cell RNA sequencing (scRNA-seq) identify distinct subpopulations lesional patients. show these are enriched differ metabolism, observation corroborated both MPM scRNA-seq. Systematic investigation cell-cell communication CXCL prominent signaling change this small population keratinocytes, which secrete CXCL9 CXCL10 create local inflammatory cytokine loops with drive persistence. Further patients undergoing punch grafting treatment showed metabolically altered non-responders normalize responders. In summary, we couple advanced transcriptomics bioinformatics discover networks keratinocyte cell states potentially prevent repigmentation.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.05.139